Pico is the main, titular character of the Pico franchise created by Tom Fulp, founder of Newgrounds; Darnell (Newgrounds) and Nene (Newgrounds) are also main characters within the franchise. Pico first appeared in his own eponymous game: Pico's School. In Pico's School, he stops a school shooting lead by Cassandra (Newgrounds) and the Goth Punks. Pico was the main mascot of Newgrounds before being replaced by Tankman. Ever since 2006, there is an annual Newgrounds holiday called Pico Day, a celebration of Newgrounds and its mascots.
Pico has appeared as an antagonist and future playable character in Friday Night Funkin.